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Dementia
Nature Reviews Neurology (2024)
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Current dementia research has developed complex models of environmental–genetic interactions to better address multimodal disease phenotypes. New evidence highlights a stronger effect of social determinants of health than ancestry effects specific to Latin America and the Caribbean, which opens new agendas to address the diversity of these interactions in ageing and dementia.
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A.I. and A.S. are partially supported by grants from ANID/FONDECYT Regular (1210195, 1210176 and 1231839); ANID/FONDAP/15150012; ANID/PIA/ANILLOS ACT210096; and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA (ReDLat, supported by Fogarty International Center (FIC) and National Institutes of Health, National Institutes of Aging (R01 AG057234, R01 AG075775, R01 AG021051, CARDS-NIH), Alzheimer’s Association (SG-20-725707), Rainwater Charitable foundation – Tau Consortium, the Bluefield Project to Cure Frontotemporal Dementia, and Global Brain Health Institute)). A.I. is partially supported by ANID/FONDECYT Regular 1220995. The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation.
Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago, Chile
Agustin Ibanez
Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
Agustin Ibanez
Geroscience Center for Brain Health and Metabolism, Santiago, Chile
Andrea Slachevsky
Memory and Neuropsychiatric Center, Neurology Department, Hospital del Salvador & Faculty of Medicine, University of Chile, Santiago, Chile
Andrea Slachevsky
Neuropsychology and Clinical Neuroscience Laboratory, Physiopathology Department, Institute of Biomedical Sciences, Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile
Andrea Slachevsky
Neurology and Psychiatry Department, Clínica Alemana-University Desarrollo, Santiago, Chile
Andrea Slachevsky
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Correspondence to Agustin Ibanez or Andrea Slachevsky.
The authors declare no competing interests.
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Ibanez, A., Slachevsky, A. Environmental–genetic interactions in ageing and dementia across Latin America. Nat Rev Neurol (2024). https://doi.org/10.1038/s41582-024-00998-0
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DOI: https://doi.org/10.1038/s41582-024-00998-0
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